Art and the body: The Tatsuno Art Project

The author discusses the relationship between art and the body, as exemplified by the similarities and differences in the works of: two Japanese artists, Matsui Chie (b. 1960) and Higashikage Tomohiro (b. 1978); and the Polish artist, Mirosław Bałka (b. 1958). These examples are referred to in the context of a unique project recently conducted in Japan — the Tatsuno Art Project 2013. Held with the support of the Agency for Cultural Affairs of Japan, the project aims to present contemporary art to people from across Japan and around the globe, and to capitalize on the region’s unique cultural heritage, creating opportunities for people to communicate with local residents and making Tatsuno a more dynamic and popular place to visit. This paper considers various connections between art and the body by focusing on a selection of works included in the Tatsuno Art Project 2013: Arts and Memories. Known in past centuries as the ‘little Kyoto’ of Harima Province, Tatsuno is an atmospheric old castle town. It is mild and relatively warm all year round, with the climate of the nearby Seto Inland Sea region, said to be similar to that of the Mediterranean. Thanks to the support of numerous people, the organizers were able to hold the 2013 event which represented the culmination of their efforts over the past few years, being the largest ever in terms of scale with nine invited artists, eleven other participating artists, and one contemporary musician, for a total of 21 creators contributing works. With new spaces added to create a total of 16 venues, the community‑wide project truly achieved its goal of presenting the ‘historic castle town as a museum’. The project curators were also able to strengthen Tatsuno’s international ties by inviting artists from France and Poland to take part, as well as Japanese artists residing in the UK and Spain

An Open Design Theory for Society : From Oskar Hansen’s “Open Form” to Grzegorz Kowalski’s “Common Space, Private Space”

In this paper I will discuss the “Open Form” theory advocated by the Polish architect, designer, and sculptor Oskar Hansen, and a theory based on Hansen’s ideas called “common space, private space,” which was developed by Grzegorz Kowalski, a professor at the Academy of Fine Arts, Warsaw. Kowalski’s studio, called Kowalnia, has produced many students that went on to successful international art careers. I will also discuss the design theory passed down by Kowalnia and other didactics. Hansen’s innovative “Open Form” concept was opposed to much of the architecture that was prevalent at the beginning of 20th century. It was based on predetermined “closed forms,” and envisioned imaginary residents occupying a building. Hansen’s presented a new, unprecedented model, which focused on the needs and desires of individuals within groups based on “open forms” that incorporated people’s opinions and gradually changed according to various events and shifts. Recognizing that there is no such thing as an expert architect versed in all fields, the “Open Form” theory proposed that the essential guiding force behind architecture ought to be the active and organic involvement of its users. This theory was expanded beyond architecture, and applied to all aspects of art theory.Theme I : Design Theories and Ideas in Europ

Normal tissue effect and growth delay of transplanted cancer in mice by synchrotron generated microplaner beam

13th International Congress of Radiation Researc

Ultraviolet B-induced maturation of CD11b-Type Langerin² dendritic cells controls the expansion of foxp3⁺ regulatory t cells in the skin

Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin2 DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin2 DCs upregulated surface CD86 expression, induced proliferation of Foxp3+ regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin2 DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.</p

Novel Immunoliposome Technology for Enhancing the Activity of the Agonistic Antibody against the Tumor Necrosis Factor Receptor Superfamily

We have developed a technology for efficiently enhancing the anticancer apoptosis-inducing activity of agonistic antibodies against the tumor necrosis factor receptor (TNFR) superfamily by the formation of immunoliposomes. To induce apoptosis in cancer cells, agonistic antibodies to the TNFR superfamily normally need cross-linking by internal immune effector cells via the Fc region after binding to receptors on the cell membrane. To develop apoptosis-inducing antibodies that do not require the support of cross-linking by immune cells, we prepared immunoliposomes conjugated with TRA-8, an agonistic antibody against death receptor 5 (DR5), with various densities of antibody on the liposome surface, and evaluated their activities. The TRA-8 immunoliposomes exhibited apoptosis-inducing activity against various DR5-positive human carcinoma cells at a significantly lower concentration without cross-linking than that of the original TRA-8 and its natural ligand (TRAIL). The activity of the immunoliposomes was correlated with the density of antibodies on the surface. As the antibody component, not only the full-length antibody but also the Fab′ fragment could be used, and the TRA-8 Fab′ immunoliposomes also showed exceedingly high activity compared with the parental antibody, namely, TRA-8. Moreover, cytotoxicity of the TRA-8 full-length or Fab′ immunoliposome against normal cells, such as human primary hepatocytes, was lower than that for TRAIL. Enhanced activity was also observed for immunoliposomes conjugated with other apoptosis-inducing antibodies against other receptors of the TNFR superfamily, such as death receptor 4 (DR4) and Fas. Thus, immunoliposomes are promising as a new modality that could exhibit significant activity at a low dose, for cost-effective application of an antibody fragment and with stable efficacy independent of the intratumoral environment of patients as a TNF superfamily agonistic therapy

Automated Quantification of Extranuclear ERα Using Phosphor-Integrated Dots for Predicting Endocrine Therapy Resistance in HR⁺/HER2⁻ Breast Cancer

In addition to genomic signaling, Estrogen receptor alpha (ER&#945;) is associated with cell proliferation and survival through extranuclear signaling contributing to endocrine therapy (ET) resistance. However, the relationship between extranuclear ER&#945; and ET resistance has not been extensively studied. We sought to measure extranuclear ER&#945; expression by immunohistochemistry using phosphor-integrated dots (IHC-PIDs) and to assess its predictive value for ET resistance. After quantitative detection of ER&#945; by IHC-PIDs in vitro, we developed &#8220;the nearest-neighbor method&#8222; to calculate the extranuclear ER&#945;. Furthermore, tissue sections from 65 patients with HR+/HER2- BC were examined by IHC-PIDs, and the total ER&#945;, nuclear ER&#945;, extranuclear ER&#945; PIDs score, and ratio of extranuclear-to-nuclear ER&#945; (ENR) were measured using the novel method. We demonstrate that quantification of ER&#945; using IHC-PIDs exhibited strong correlations to real-time qRT-PCR (r2 = 0.94) and flow cytometry (r2 = 0.98). High ER&#945; ENR was significantly associated with poor overall survival (p = 0.048) and disease-free survival (DFS) (p = 0.007). Multivariate analysis revealed that the ER&#945; ENR was an independent prognostic factor for DFS [hazard ratio, 3.8; 95% CI, 1.4&#8211;11.8; p = 0.006]. Our automated measurement has high accuracy to localize and assess extranuclear ER&#945;. A high ER&#945; ENR in HR+/HER2&#8722; BC indicates decreased likelihood of benefiting from ET